2-(4-Fluorophenyl)acetic acid → HCID 21971838, compound

HRID 367367Notes

Reaction equation

HRID 367367 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.O[C@:13]([CH3:28])([CH2:26][CH3:27])[C:14]([C:16]1[CH:21]=[CH:20][C:19]([S:22]([CH3:25])(=[O:24])=[O:23])=[CH:18][CH:17]=1)=O>>[CH2:26]([C@@:13]1([CH3:28])[O:10][C:9](=[O:11])[C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)=[C:14]1[C:16]1[CH:21]=[CH:20][C:19]([S:22]([CH3:25])(=[O:23])=[O:24])=[CH:18][CH:17]=1)[CH3:27]

Participants

3

Reactant 2

HCID 98372-(4-Fluorophenyl)acetic acidHCID 22880248HCID 22880248, compound

Product 1

HCID 21971838HCID 21971838, compound

Procedure

Using the procedures described in Example 1, Step 4 and Step 5, replacing phenylacetic acid with p-fluorophenylacetic acid and replacing 2-hydroxy-2-methyl-1-[4-(methylsulfonyl)phenyl]-1-butanone with (2R)-2-hydroxy-2-methyl-1-[4-(methylsulfonyl)phenyl]butan-1-one from Step 4, the title compound was obtained as a white solid.

Sources & evidence

ORD record
ord-b1a6d8933e4545ba897f1682eb210784
Source dataset
uspto-grants-2000_10
Patent number
US06133292

Reaction notes

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