4-t-Butylbenzenesulfonyl chloride → HCID 23288161, compound

HRID 367375Notes

Reaction equation

HRID 367375 reaction equation
[CH:1]1([O:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][CH:12]=[C:11]3[C:17]2[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH:22]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:24]([C:28]1[CH:33]=[CH:32][C:31]([S:34](Cl)(=[O:36])=[O:35])=[CH:30][CH:29]=1)([CH3:27])([CH3:26])[CH3:25]>>[C:24]([C:28]1[CH:33]=[CH:32][C:31]([S:34]([N:13]2[C:14]3[C:10](=[CH:9][C:8]([O:7][CH:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)=[CH:16][CH:15]=3)[C:11]([C:17]3[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH:22]=3)=[CH:12]2)(=[O:36])=[O:35])=[CH:30][CH:29]=1)([CH3:27])([CH3:25])[CH3:26]

Participants

3

Reactant 2

HCID 1398824-t-Butylbenzenesulfonyl chlorideHCID 232881505-(Cyclohexyloxy)-3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indole

Product 1

HCID 23288161HCID 23288161, compound

Procedure

(34.0 mg, 81%); from 5-cyclohexyloxy-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (Example 4c, 25.6 mg, 0.082 mmol) and 4-t-butylphenylsulfonyl chloride (37.2 mg, 0.16 mmol); HRMS-FAB+ for C30H38N2O3S: calculated MH+ : 507.26813; found: 507.27183.

Sources & evidence

ORD record
ord-1587f854c4374d8198b74a4203690948
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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