4-t-Butylbenzenesulfonyl chloride → HCID 23288116, compound

HRID 367379Notes

Reaction equation

HRID 367379 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]1[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=1.[C:18]([C:22]1[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=1)([CH3:21])([CH3:20])[CH3:19]>>[C:18]([C:22]1[CH:27]=[CH:26][C:25]([S:28]([N:7]2[C:8]3[C:4](=[CH:3][C:2]([F:1])=[CH:10][CH:9]=3)[C:5]([C:11]3[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=3)=[CH:6]2)(=[O:30])=[O:29])=[CH:24][CH:23]=1)([CH3:21])([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 1398824-t-Butylbenzenesulfonyl chlorideHCID 149732095-fluoro-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole

Product 1

HCID 23288116HCID 23288116, compound

Procedure

(23.0 mg, 42%), from 5-fluoro-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (Example 4b, 29.4 mg, 0.128 mmol) and 4-t-butylphenylsulfonyl chloride (59.6 mg, 0.26 mmol); HRMS-FAB+ for C24H28N2O2SF calculated MH+ : 427.18555; found: 427.18680.

Sources & evidence

ORD record
ord-fa361ea223504d0988a573fd2198610d
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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