3-Nitrobenzenesulfonyl chloride → HCID 23288127, compound

HRID 367380Notes

Reaction equation

HRID 367380 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:11]1[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=1.[N+:18]([C:21]1[CH:22]=[C:23]([S:27](Cl)(=[O:29])=[O:28])[CH:24]=[CH:25][CH:26]=1)([O-:20])=[O:19]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:27]([C:23]1[CH:24]=[CH:25][CH:26]=[C:21]([N+:18]([O-:20])=[O:19])[CH:22]=1)(=[O:28])=[O:29])[CH:6]=[C:5]2[C:11]1[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=1

Participants

3

Reactant 2

HCID 84763-Nitrobenzenesulfonyl chlorideHCID 149732095-fluoro-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole

Product 1

HCID 23288127HCID 23288127, compound

Procedure

(31.0 mg, 56%), from 5-fluoro-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (Example 4b, 30.1 mg, 0.131 mmol) and 3-nitrophenylsulfonyl chloride (58.1 mg, 0.26 mmol); HRMS-FAB+ for C20H19N3O4SF calculated MH+ : 416.10803; found: 416.10631.

Sources & evidence

ORD record
ord-4f53025a3cc64ce8a0507eedded10283
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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