HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 23288076, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Fluorobenzenesulfonyl chloride | HCID 9588 | — |
| Reactant | HCID 3061874 | HCID 3061874 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 23288076 | HCID 23288076 | 80.5% |
Reaction Steps
from 5-chloro-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (Example 4d, 25 mg, 0.1 mmol) and 4-fluorophenylsulfonyl chloride (29.1 mg, 0.15 mmol). The HCl salt ether (32.6 mg, 74%) was prepared from the crude product using 1M HCl in ether. m.p 256-7° C., HRMS-FAB+ for C20H18N2O2SClF.HCl, calculated MH+ (--HCl): 405.08398; found: 405.0797.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133287 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-5271b5cc8c1a481f931be6cabfbeecba |
| Source note | uspto-grants-2000_10 |