4-Fluorobenzoyl chloride → HCID 23288146, compound

HRID 367390Notes

Reaction equation

HRID 367390 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]=[C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[F:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([N:10]2[C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:8]([C:5]3[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH:6]=3)=[CH:9]2)=[O:23])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 1522153-(1-Methyl-1,2,3,6-tetrahydropyrid-4-yl)indole

Product 1

HCID 23288146HCID 23288146, compound

Procedure

(8.7 mg, 22%); from 3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (Example 4e, 24.8 mg, 0.12 mmol) and 4-fluorobenzoyl chloride (28 uL, 0.24 mmol); HRMS-FAB+ for C21H19N2O2F: calculated MH+ : 335.15598; found: 335.15560.

Sources & evidence

ORD record
ord-6faf20b7fb2645ffb6e388679a6349a4
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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