2-Chlorobenzoyl chloride → HCID 23288144, compound

HRID 367391Notes

Reaction equation

HRID 367391 reaction equation
[CH:1]1([O:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][CH:12]=[C:11]3[C:17]2[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH:22]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:24][C:25]1[CH:33]=[CH:32][CH:31]=[CH:30][C:26]=1[C:27](Cl)=[O:28]>>[Cl:24][C:25]1[CH:33]=[CH:32][CH:31]=[CH:30][C:26]=1[C:27]([N:13]1[C:14]2[C:10](=[CH:9][C:8]([O:7][CH:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)=[CH:16][CH:15]=2)[C:11]([C:17]2[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH:22]=2)=[CH:12]1)=[O:28]

Participants

3

Reactant 2

HCID 691102-Chlorobenzoyl chlorideHCID 232881505-(Cyclohexyloxy)-3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indole

Product 1

HCID 23288144HCID 23288144, compound

Procedure

(12.5 mg, 33%); from 5-cyclohexyloxy-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (Example 4c, 25.7 mg, 0.083 mmol) and 2-chlorobenzoyl chloride (25 uL, 0.20 mmol); HRMS-FAB+ for C27H29N2O2Cl: calculated MH+ : 449.19958; found: 449.19815.

Sources & evidence

ORD record
ord-8ba3b81f0b35447a93f98704dcc3e85d
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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