2,6-Dichlorobenzoyl chloride → HCID 23288101, compound

HRID 367392Notes

Reaction equation

HRID 367392 reaction equation
[CH:1]1([O:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][CH:12]=[C:11]3[C:17]2[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH:22]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:24][C:25]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:34])[C:26]=1[C:27](Cl)=[O:28]>>[CH:1]1([O:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[N:13]([C:27](=[O:28])[C:26]2[C:25]([Cl:24])=[CH:33][CH:32]=[CH:31][C:30]=2[Cl:34])[CH:12]=[C:11]3[C:17]2[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH:22]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 783922,6-Dichlorobenzoyl chlorideHCID 232881505-(Cyclohexyloxy)-3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indole

Product 1

HCID 23288101HCID 23288101, compound

Procedure

(40.1 mg, 100%); from 5-cyclohexyloxy-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (Example 4c, 25.7 mg, 0.083 mmol) and 2,6-dichlorobenzoyl chloride (30 uL, 0.21 mmol); HRMS-FAB+ for C27H28N2O2Cl2 : calculated MH+ : 483.16061; found: 483.15611.

Sources & evidence

ORD record
ord-f9b6707700074e21ba8246bdeed311c9
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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