4-Fluorobenzoyl chloride → HCID 23288106, compound

HRID 367394Notes

Reaction equation

HRID 367394 reaction equation
[CH:1]1([O:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[NH:13][CH:12]=[C:11]3[C:17]2[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH:22]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:24][C:25]1[CH:33]=[CH:32][C:28]([C:29](Cl)=[O:30])=[CH:27][CH:26]=1>>[CH:1]1([O:7][C:8]2[CH:9]=[C:10]3[C:14](=[CH:15][CH:16]=2)[N:13]([C:29](=[O:30])[C:28]2[CH:32]=[CH:33][C:25]([F:24])=[CH:26][CH:27]=2)[CH:12]=[C:11]3[C:17]2[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH:22]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 232881505-(Cyclohexyloxy)-3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indole

Product 1

HCID 23288106HCID 23288106, compound

Procedure

(24.0 mg, 68%); from 5-cyclohexyloxy-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (Example 4c, 25.6 mg, 0.082 mmol) and 4-fluorobenzoyl chloride (25 uL, 0.21 mmol); HRMS-FAB+ for C27H29N2O2F: calculated MH+ : 433.22913; found: 433.22733.

Sources & evidence

ORD record
ord-33922e0753b34d3b907f6a98f4c2abac
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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