Benzoyl chloride → HCID 23288131, compound

HRID 367395Notes

Reaction equation

HRID 367395 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]3[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=3)=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:18]([N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([Br:1])[CH:10]=2)[C:6]([C:11]2[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH:16]=2)=[CH:7]1)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 232881216-Bromo-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

Product 1

HCID 23288131HCID 23288131, compound

Procedure

(23.2 mg, 68%); from 6-bromo-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (Example 4f, 25.0 mg, 0.086 mmol) and benzoyl chloride (20 uL, 0.17 mmol); HRMS-FAB+ for C21H19N2OBr: calculated MH+ : 395.07590; found: 395.07848.

Sources & evidence

ORD record
ord-ee5d1c3e660e4658b71ed25a1a194cf4
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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