Benzoyl chloride → HCID 23288123, compound

HRID 367398Notes

Reaction equation

HRID 367398 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]=[C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:17][C:18]([F:21])([F:20])[F:19])[CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:22](Cl)(=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:22]([N:10]1[C:11]2[C:16](=[CH:15][C:14]([O:17][C:18]([F:21])([F:19])[F:20])=[CH:13][CH:12]=2)[C:8]([C:5]2[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH:6]=2)=[CH:9]1)(=[O:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 23288118HCID 23288118, compound

Product 1

HCID 23288123HCID 23288123, compound

Procedure

(9.3 mg, 32%); from 3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-trifluoromethoxy-1H-indole (Example 4h, 20 mg, 0.068 mmol) and benzoyl chloride (15.0 mg, 0.107 mmol), HRMS-FAB+ for C22H19N2O2F3, calculated MH+ : 401.14767; found: 401.14761.

Sources & evidence

ORD record
ord-5c7671b1393f4db19371c28b698aae18
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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