Benzoyl chloride → HCID 23288147, compound

HRID 367402Notes

Reaction equation

HRID 367402 reaction equation
[CH3:1][N:2]1[CH2:7][CH:6]=[C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17]([F:20])([F:19])[F:18])[CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:21]([Cl:29])(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[ClH:29].[C:21]([N:10]1[C:11]2[C:16](=[CH:15][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:13][CH:12]=2)[C:8]([C:5]2[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH:6]=2)=[CH:9]1)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 232880753-(1,2,3,6-Tetrahydro-1-methyl-4-pyridinyl)-5-(trifluoromethyl)-1H-indole

Product 1

HCID 23288147HCID 23288147, compound

Procedure

(20.3 mg, 74%); from 3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-5-trifluoromethyl-1H-indole (Example 4i, 20 mg, 0.071 mmol) and benzoyl chloride (15.0 mg, 0.107 mmol), HRMS-FAB+ for C22H19N2OF3, calculated MH+ : 385.15277; found: 385.15480.

Sources & evidence

ORD record
ord-cb056f21da694604978484965efe984d
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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