Benzenesulfonyl chloride → HCID 23288142, compound

HRID 367407Notes

Reaction equation

HRID 367407 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:17]1([S:23](Cl)(=[O:25])=[O:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]([S:23]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)(=[O:25])=[O:24])[CH:9]=2)[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 112066723-(1-Methylpiperidin-4-yl)-1H-indole

Product 1

HCID 23288142HCID 23288142, compound

Procedure

(23.9 mg, 67%) from 3-(1-methyl-4-piperidinyl)-1H-indole (Example 5d, 21.5 mg, 0.1 mmol) and phenylsulfonyl chloride (26.4 mg, 0.15 mmol), HRMS-FAB+ for C20H22N2O2S, calculated MH+ : 355.14807; found: 355.15074.

Sources & evidence

ORD record
ord-b6c2cc772b734252a3729a051e496caf
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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