4-Fluorobenzenesulfonyl chloride → HCID 23288111, compound

HRID 367408Notes

Reaction equation

HRID 367408 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[F:17][C:18]1[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([N:10]2[C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:8]([CH:5]3[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]3)=[CH:9]2)(=[O:26])=[O:25])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 112066723-(1-Methylpiperidin-4-yl)-1H-indole

Product 1

HCID 23288111HCID 23288111, compound

Procedure

(17.0 mg, 46%), from 3-(1-methyl-4-piperidinyl)-1H-indole (Example 5d, 21.5 mg, 0.1 mmol) and 4-fluorophenylsulfonyl chloride (29.2 mg, 0.15 mmol), HRMS-FAB+ for C20H21N2O2SF, calculated MH+ : 373.13861; found: 373.13669.

Sources & evidence

ORD record
ord-d5c86a0ce25846b1803e23e9d374cf81
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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