Benzenesulfonyl chloride → HCID 23288098, compound

HRID 367410Notes

Reaction equation

HRID 367410 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[C:18]1([S:24](Cl)(=[O:26])=[O:25])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:24]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)(=[O:26])=[O:25])[CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 113452965-Fluoro-3-(1-methyl-4-piperidinyl)indole

Product 1

HCID 23288098HCID 23288098, compound

Procedure

(27.3 mg, 73%) from 5-fluoro-3-(1-methyl-4-piperidinyl)-1H-indole (Example 5c, 25 mg, 0.1 mmol) and phenylsulfonyl chloride (26.4 mg, 0.15 mmol), HRMS-FAB+ for C20H21N2O2SF, calculated MH+ : 373.13861; found: 373.13569.

Sources & evidence

ORD record
ord-2dfa67d8069e4c7ba7109b2dfa6b0b09
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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