4-Fluorobenzenesulfonyl chloride → HCID 23288141, compound

HRID 367411Notes

Reaction equation

HRID 367411 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[F:18][C:19]1[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:24]=[CH:23][C:22]([S:25]([N:7]2[C:8]3[C:4](=[CH:3][C:2]([F:1])=[CH:10][CH:9]=3)[C:5]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:6]2)(=[O:27])=[O:26])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 95884-Fluorobenzenesulfonyl chlorideHCID 113452965-Fluoro-3-(1-methyl-4-piperidinyl)indole

Product 1

HCID 23288141HCID 23288141, compound

Procedure

(22.6 mg, 58%) from 5-fluoro-3-(1-methyl-4-piperidinyl)-1H-indole (Example 5c, 25 mg, 0.1 mmol) and 4-fluorophenylsulfonyl chloride (29.2 mg, 0.15 mmol), HRMS- FAB+ for C20H20N2O2SF2, calculated MH+ : 391.12918; found: 391.12926.

Sources & evidence

ORD record
ord-a0a88b1dc4ab42418fccf1d23016c97c
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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