Benzoyl chloride → HCID 23288088, compound

HRID 367412Notes

Reaction equation

HRID 367412 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:18]([N:7]1[C:8]2[C:4](=[CH:3][C:2]([Cl:1])=[CH:10][CH:9]=2)[C:5]([CH:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[CH:6]1)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 114139925-Chloro-3-(1-methyl-4-piperidinyl)indole

Product 1

HCID 23288088HCID 23288088, compound

Procedure

(23.0 mg, 65%); from 5-chloro-3-(1-methyl-4-piperidinyl)-1H-indole (Example 5e, 25 mg, 0.10 mmol) and benzoyl chloride (21.1 mg, 0.15 mmol), HRMS-FAB+ for C21H21N2OCl, calculated MH+ : 353.14206; found: 353.14033.

Sources & evidence

ORD record
ord-9cdfbe21fcbe4cc49154726ab3e87dc6
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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