4-Fluorobenzoyl chloride → HCID 23288120, compound

HRID 367413Notes

Reaction equation

HRID 367413 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[F:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:23](=[O:24])[C:22]1[CH:26]=[CH:27][C:19]([F:18])=[CH:20][CH:21]=1)[CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 114139925-Chloro-3-(1-methyl-4-piperidinyl)indole

Product 1

HCID 23288120HCID 23288120, compound

Procedure

(22.5 mg, 61%); from 5-chloro-3-(1-methyl-4-piperidinyl)-1H-indole (Example 5e, 25 mg, 0.10 mmol) and 4-fluorobenzoyl chloride (23.8 mg, 0.15 mmol), HRMS-FAB+ for C21H20N2OClF, calculated MH+ : 371.13263; found: 371.13063.

Sources & evidence

ORD record
ord-c2fa8afca3fa4fc5b4bca0ee8b5ec602
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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