Benzoyl chloride → HCID 23288164, compound

HRID 367414Notes

Reaction equation

HRID 367414 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:17](Cl)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:17]([N:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([CH:5]2[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]2)=[CH:9]1)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 112066723-(1-Methylpiperidin-4-yl)-1H-indole

Product 1

HCID 23288164HCID 23288164, compound

Procedure

(28.1 mg, 88%); from 3-(1-methyl-4-piperidinyl)-1H-indole (Example 5d, 21.5 mg, 0.10 mmol) and benzoyl chloride (21.1 mg, 0.15 mmol), HRMS-FAB+ for C21H21N2O, calculated MH+ : 319.18103; found: 319.18293.

Sources & evidence

ORD record
ord-3012ae347d364735be34d23b92837455
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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