4-Fluorobenzoyl chloride → HCID 23288162, compound

HRID 367415Notes

Reaction equation

HRID 367415 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[F:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([N:10]2[C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:8]([CH:5]3[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]3)=[CH:9]2)=[O:23])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 112066723-(1-Methylpiperidin-4-yl)-1H-indole

Product 1

HCID 23288162HCID 23288162, compound

Procedure

(27.2 mg, 81%); from 3-(1-methyl-4-piperidinyl)-1H-indole (Example 5d, 21.5 mg, 0.10 mmol) and 4-fluorobenzoyl chloride (23.8 mg, 0.15 mmol), HRMS-FAB+ for C21H21N2OF, calculated MH+ : 337.17163; found: 337.17162.

Sources & evidence

ORD record
ord-724a9ce903604c52b187522e5709c4c1
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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