Benzoyl chloride → HCID 23288084, compound

HRID 367416Notes

Reaction equation

HRID 367416 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:18]([N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:10]=2)[C:6]([CH:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[CH:7]1)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 187973681H-Indole, 6-chloro-3-(1-methyl-4-piperidinyl)-

Product 1

HCID 23288084HCID 23288084, compound

Procedure

(25.4 mg, 72%); from 6-chloro-3-(1-methyl-4-piperidinyl)-1H-indole (Example 5b, 25 mg, 0.10 mmol) and benzoyl chloride (21.1 mg, 0.15 mmol), HRMS-FAB+ for C21H21ClN2O, calculated MH+ : 353.14206; found: 353.13873.

Sources & evidence

ORD record
ord-7a17ac2be8114e2bbaa4ffafd29333fb
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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