4-Fluorobenzoyl chloride → HCID 23288093, compound

HRID 367417Notes

Reaction equation

HRID 367417 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[F:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([N:7]2[C:8]3[C:4](=[CH:3][C:2]([F:1])=[CH:10][CH:9]=3)[C:5]([CH:11]3[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]3)=[CH:6]2)=[O:24])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 113452965-Fluoro-3-(1-methyl-4-piperidinyl)indole

Product 1

HCID 23288093HCID 23288093, compound

Procedure

(25.1 mg, 71%); from 5-fluoro-3-(1-methyl-4-piperidinyl)-1H-indole (Example 5c, 23.0 mg, 0.10 mmol) and 4-fluorobenzoyl chloride (23.8 mg, 0.15 mmol), HRMS-FAB+ for C21H20N2OF2, calculated MH+ : 355.16220; found: 355.16313.

Sources & evidence

ORD record
ord-cdd82197f02549df8f2afddcdfa63dfb
Source dataset
uspto-grants-2000_10
Patent number
US06133287

Reaction notes

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