HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-Chloro-6-methyl-4-(3,4-methylenedioxybenzylamino)thieno-[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzo-1,3-dioxole-5-methylamine | HCID 75799 | — |
| Reactant | 2,4-Dichloro-6-methylthieno[2,3-D]pyrimidine | HCID 11106847 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Chloro-6-methyl-4-(3,4-methylenedioxybenzylamino)thieno-[2,3-d]pyrimidine | HCID 10958561 | — |
Reaction Steps
A solution of 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine (3.29 g) in dichloromethane (30 ml) is charged with 3,4-methylenedioxybenzylamine ("A") (3.02 g). Triethylamine (1.52 g) is added, and the mixture is stirred at room temperature. The solvent is removed, and the usual workup yields 2-chloro-6-methyl-4-(3,4-methylenedioxybenzylamino)-thieno-[2,3-d]-pyrimidine (3.38 g) Mp. 162° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133271 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-b84f985c588f4df4a7272decf2a3e86a |
| Source note | uspto-grants-2000_10 |