4-Fluorobenzylamine → 2,4-Dichloro-5-methylthieno(2,3-d)pyrimidine

HRID 367455Notes

Reaction equation

HRID 367455 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.[Cl:10][C:11]1[N:12]=[C:13]([Cl:21])[C:14]2[CH:19]=[C:18]([CH3:20])[S:17][C:15]=2[N:16]=1>>[Cl:10][C:11]1[N:12]=[C:13]([NH:7][CH2:6][C:5]2[CH:8]=[CH:9][C:2]([F:1])=[CH:3][CH:4]=2)[C:14]2[CH:19]=[C:18]([CH3:20])[S:17][C:15]=2[N:16]=1.[Cl:10][C:11]1[N:12]=[C:13]([Cl:21])[C:14]2[C:19]([CH3:2])=[CH:18][S:17][C:15]=2[N:16]=1

Participants

4

Reactant 2

HCID 673264-FluorobenzylamineHCID 111068472,4-Dichloro-6-methylthieno[2,3-D]pyrimidine

Product 2

HCID 122252992,4-Dichloro-5-methylthieno(2,3-d)pyrimidineHCID 184603832-Chloro-6-methyl-4-(4-fluorobenzylamino)-thieno-[2,3-d]-pyrimidine

Procedure

Following the procedure of Example 1, the reaction of 4-fluorobenzylamine with 2,4-dichloro-6-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-6-methyl-4-(4-fluorobenzylamino)-thieno-[2,3-d]-pyrimidine with 2,4-dichloro-5-methyl-thieno-[2,3-d]-pyrimidine yields 2-chloro-5-methyl-4-(4-fluorobenzylamino)-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record
ord-1840b43276ce4d9a826ff2a7d42af7e1
Source dataset
uspto-grants-2000_10
Patent number
US06133271

Reaction notes

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