HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 2-(Imidazol-1-yl)-6-methyl-4-(3,4-methylenedioxybenzylamino)thieno[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Phenol | HCID 996 | — |
| Reactant | 2-Chloro-6-methyl-4-(3,4-methylenedioxybenzylamino)thieno-[2,3-d]pyrimidine | HCID 10958561 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(Imidazol-1-yl)-6-methyl-4-(3,4-methylenedioxybenzylamino)thieno[2,3-d]pyrimidine | HCID 9842055 | 184.9% |
Reaction Steps
A solution of 2-chloro-6-methyl-4-(3,4-methylene dioxybenzylamino)-thieno-[2,3-d]-pyrimidine (1.67 g), imidazole (1.02 g) and phenol (2 g) are heated 5 hours at 150° C. After cooling, the residue is dissolved in CH2Cl2. The solvent is removed, and the usual workup yields 2-(imidazol-1-yl)-6-methyl-4-(3,4-methylenedioxybenzylamino)-thieno-[2,3-d]-pyrimidine (3.38 g) Mp. 162° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133271 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-58cdef45f389413382ec12acb85234b7 |
| Source note | uspto-grants-2000_10 |