2-Methylimidazole → 2-(2-Methylimidazol-1-yl)-6-nitro-4-benzylamino-thieno-[2,3-d]-pyrimidine

HRID 367721Notes

Reaction equation

[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1.Cl[C:8]1[N:9]=[C:10]([NH:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[S:14][C:12]=2[N:13]=1>>[CH3:1][C:2]1[N:3]([C:8]2[N:9]=[C:10]([NH:20][CH2:21][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[C:11]3[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[S:14][C:12]=3[N:13]=2)[CH:4]=[CH:5][N:6]=1

Participants

Reactant 2

HCID 127492-Methylimidazole

HCID 184600152-Chloro-6-nitro-4-benzylamino-thieno-[2,3-d]-pyrimidine

Product 1

HCID 184604252-(2-Methylimidazol-1-yl)-6-nitro-4-benzylamino-thieno-[2,3-d]-pyrimidine

Procedure

Following the procedure of Example 97, the reaction of 2-methylimidazole with 2-chloro-6-nitro-4-benzylamino-thieno-[2,3-d]-pyrimidine gives 2-(2-methylimidazol-1-yl)-6-nitro-4-benzylamino-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record: ord-e531ee7952b642ba8075d00520a42fc2
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06133271

Reaction notes

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