HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine-2-carbonitrile → 4-Chloro-2-(pyridin-2-yl)-6-ethyl-thieno-[2,3-d]-pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine-2-carbonitrile | HCID 7522 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Ethyl 2-amino-5-ethyl-3-thenoate | HCID 78263 | — |
| Product | 4-Chloro-2-(pyridin-2-yl)-6-ethyl-thieno-[2,3-d]-pyrimidine | HCID 18460329 | — |
Reaction Steps
With the procedure of Example 477, the reaction of 2-cyanopyridine and 2-amino-5-ethyl-3-ethoxycarbonyl-thiophene, and the subsequent reaction With POCl3 yields 4-chloro-2-(pyridin-2-yl)-6-ethyl-thieno-[2,3-d]-pyrimidine
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133271 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-e6ca876d7447496caba45d805ae322c5 |
| Source note | uspto-grants-2000_10 |