Benzylamine → 2-(Pyridin-3-yl)-4-benzylamino-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine

HRID 367840Notes

Reaction equation

HRID 367840 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:10]1[C:11]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[S:22][C:12]=2[N:13]=[C:14]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)[N:15]=1>>[N:18]1[CH:19]=[CH:20][CH:21]=[C:16]([C:14]2[N:15]=[C:10]([NH:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:11]3[CH:24]=[C:23]([C:25]([F:28])([F:26])[F:27])[S:22][C:12]=3[N:13]=2)[CH:17]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 184604174-Chloro-2-(pyridin-3-yl)-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine

Product 1

HCID 184603722-(Pyridin-3-yl)-4-benzylamino-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine

Procedure

With the procedure of Example 1, the reaction of benzylamine with 4-chloro-2-(pyridin-3-yl)-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine yields 2-(pyridin-3-yl)-4-benzylamino-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record
ord-556104bbc53b4de2ad51713f65607cba
Source dataset
uspto-grants-2000_10
Patent number
US06133271

Reaction notes

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