Benzylamine → 2-(Pyridin-4-yl)-4-benzylamino-5-methyl-thieno-[2,3-d]-pyrimidine

HRID 367863Notes

Reaction equation

HRID 367863 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[C:10]1[C:11]2[C:24]([CH3:25])=[CH:23][S:22][C:12]=2[N:13]=[C:14]([C:16]2[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=2)[N:15]=1>>[N:19]1[CH:18]=[CH:17][C:16]([C:14]2[N:15]=[C:10]([NH:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:11]3[C:24]([CH3:25])=[CH:23][S:22][C:12]=3[N:13]=2)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 184598924-Chloro-2-(pyridin-4-yl)-5-methyl-thieno-[2,3-d]-pyrimidine

Product 1

HCID 184598672-(Pyridin-4-yl)-4-benzylamino-5-methyl-thieno-[2,3-d]-pyrimidine

Procedure

With the procedure of Example 1, the reaction of benzylamine with 4-chloro-2-(pyridin-4-yl)-5-methyl-thieno-[2,3-d]-pyrimidine yields 2-(pyridin-4-yl)-4-benzylamino-5-methyl-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record
ord-3fcca224e0934968bf9c7c2f49a066e1
Source dataset
uspto-grants-2000_10
Patent number
US06133271

Reaction notes

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