4-Chloro-2-(pyridin-3-yl)-5-methyl-thieno-[2,3-d]-pyrimidine → 2-(Pyridin-3-yl)-4-(4-fluorobenzylamino)-5-methyl-thieno-[2,3-d]-pyrimidine

HRID 367869Notes

Reaction equation

HRID 367869 reaction equation
F[C:2]1([F:10])[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH2:3]1.Cl[C:12]1[C:13]2[C:26]([CH3:27])=[CH:25][S:24][C:14]=2[N:15]=[C:16]([C:18]2[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=2)[N:17]=1>>[N:20]1[CH:21]=[CH:22][CH:23]=[C:18]([C:16]2[N:17]=[C:12]([NH:7][CH2:6][C:5]3[CH:4]=[CH:3][C:2]([F:10])=[CH:9][CH:8]=3)[C:13]3[C:26]([CH3:27])=[CH:25][S:24][C:14]=3[N:15]=2)[CH:19]=1

Participants

3

Reactant 2

HCID 184600144-Chloro-2-(pyridin-3-yl)-5-methyl-thieno-[2,3-d]-pyrimidineHCID 701442864-Fluoro-4-fluorobenzylamine

Product 1

HCID 184603582-(Pyridin-3-yl)-4-(4-fluorobenzylamino)-5-methyl-thieno-[2,3-d]-pyrimidine

Procedure

With the procedure of Example 1, the reaction of 4-fluoro-4-fluorobenzylamine with 4-chloro-2-(pyridin-3-yl)-5-methyl-thieno-[2,3-d]-pyrimidine yields 2-(pyridin-3-yl)-4-(4-fluorobenzylamino)-5-methyl-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record
ord-28791ae73cc54c74ba930e25dbc2c585
Source dataset
uspto-grants-2000_10
Patent number
US06133271

Reaction notes

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