4-Fluorobenzylamine → HCID 18459972, compound

HRID 367900Notes

Reaction equation

HRID 367900 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.Cl[C:11]1[C:12]2[CH:25]=[C:24]([C:26]([F:29])([F:28])[F:27])[S:23][C:13]=2[N:14]=[C:15]([C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)[N:16]=1>>[N:20]1[CH:21]=[CH:22][C:17]([C:15]2[N:16]=[C:11]([NH:7][CH2:6][C:5]3[CH:8]=[CH:9][C:2]([F:1])=[CH:3][CH:4]=3)[C:12]3[CH:25]=[C:24]([C:26]([F:28])([F:27])[F:29])[S:23][C:13]=3[N:14]=2)=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 673264-FluorobenzylamineHCID 184600504-Chloro-2-(pyridin-4-yl)-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine

Product 1

HCID 18459972HCID 18459972, compound

Procedure

With the procedure of Example 1, the reaction of 4-fluorobenzylamine with 4-chloro-2-(pyridin-4-yl)-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine yields 2-(pyridin-4-yl)-4-(4-fluorobenzylamino)-6-trifluoromethyl-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record
ord-6d776da6c88f439194fa06f9bfe57eb4
Source dataset
uspto-grants-2000_10
Patent number
US06133271

Reaction notes

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