4-Chloro-2-(pyridin-3-yl)-5-methyl-thieno-[2,3-d]-pyrimidine → 2-(Pyridin-3-yl)-4-(3-nitrobenzylamino)-5-methyl-thieno-[2,3-d]-pyrimidine

HRID 368003Notes

Reaction equation

HRID 368003 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].Cl[C:14]1[C:15]2[C:28]([CH3:29])=[CH:27][S:26][C:16]=2[N:17]=[C:18]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[N:19]=1>>[N:22]1[CH:23]=[CH:24][CH:25]=[C:20]([C:18]2[N:19]=[C:14]([NH:7][CH2:6][C:5]3[CH:8]=[CH:9][CH:2]=[C:3]([N+:10]([O-:12])=[O:11])[CH:4]=3)[C:15]3[C:28]([CH3:29])=[CH:27][S:26][C:16]=3[N:17]=2)[CH:21]=1

Participants

3

Reactant 2

HCID 184600144-Chloro-2-(pyridin-3-yl)-5-methyl-thieno-[2,3-d]-pyrimidineHCID 18460110(4-Fluoro-3-nitrophenyl)methanamine

Product 1

HCID 184598642-(Pyridin-3-yl)-4-(3-nitrobenzylamino)-5-methyl-thieno-[2,3-d]-pyrimidine

Procedure

With the procedure of Example 1, the reaction of 4-fluoro-3-nitrobenzylamine with 4-chloro-2-(pyridin-3-yl)-5-methyl-thieno-[2,3-d]-pyrimidine yields 2-(pyridin-3-yl)-4-(3-nitrobenzylamino)-5-methyl-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record
ord-b9b5bd33cf8c4318aff6c4b9fff9f117
Source dataset
uspto-grants-2000_10
Patent number
US06133271

Reaction notes

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