3-Nitrobenzylamine → 2-(Isoxazol-5-yl)-4-(3-nitrobenzylamino)-6-nitro-thieno-[2,3-d]-pyrimidine

HRID 368013Notes

Reaction equation

[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH2:8])([O-:3])=[O:2].Cl[C:13]1[C:14]2[CH:26]=[C:25]([N+:27]([O-:29])=[O:28])[S:24][C:15]=2[N:16]=[C:17]([C:19]2[O:23][N:22]=[CH:21][CH:20]=2)[N:18]=1>>[O:23]1[C:19]([C:17]2[N:18]=[C:13]([NH:8][CH2:7][C:6]3[CH:9]=[CH:10][CH:11]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=3)[C:14]3[CH:26]=[C:25]([N+:27]([O-:29])=[O:28])[S:24][C:15]=3[N:16]=2)=[CH:20][CH:21]=[N:22]1

Participants

Reactant 2

HCID 1227223-Nitrobenzylamine

HCID 184600844-Chloro-2-(isoxazol-5-yl)-6-nitro-thieno-[2,3-d]-pyrimidine

Product 1

HCID 184602612-(Isoxazol-5-yl)-4-(3-nitrobenzylamino)-6-nitro-thieno-[2,3-d]-pyrimidine

Procedure

With the procedure of Example 1, the reaction of 3-nitrobenzylamine with 4-chloro-2-(isoxazol-5-yl)-6-nitro-thieno-[2,3-d]-pyrimidine yields 2-(isoxazol-5-yl)-4-(3-nitrobenzylamino)-6-nitro-thieno-[2,3-d]-pyrimidine.

Sources & evidence

ORD record: ord-25afa42d2abf4c77a61b8381637e5c93
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06133271

Reaction notes

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