HCID 15840442, compound → HCID 15840443, compound

HRID 368279Notes

Reaction equation

HRID 368279 reaction equation
[N:1]1([C:6]2[N:7]=[C:8]([NH:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-])=O)[CH:19]=3)[C:9]3[CH:14]=[C:13]([CH3:15])[S:12][C:10]=3[N:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1>CO.[Ni]>[N:1]1([C:6]2[N:7]=[C:8]([NH:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([NH2:24])[CH:19]=3)[C:9]3[CH:14]=[C:13]([CH3:15])[S:12][C:10]=3[N:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 1

HCID 15840442HCID 15840442, compound

Product 1

HCID 15840443HCID 15840443, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A solution of 2-(Imidazol-1-yl)-6-methyl-4-(3-nitrobenzylamino)-thieno-[2,3-d]-pyrimidine in methanol is hydrogenated in the presence of Raney-nickel. The catalyst is filtered off and the solution is concentrated. Recrystallization yields 2-(imidazol-1-yl)-6-methyl-4-(3-aminobenzylamino)-thieno-[2,3-d]-pyrimidine.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe solution is concentrated
  3. customRecrystallization

Sources & evidence

ORD record
ord-55a5b9651040474c911543f895152d58
Source dataset
uspto-grants-2000_10
Patent number
US06133271

Reaction notes

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