1,1-Dimethoxyethyl(dimethyl)amine → N-[1-(Dimethylamino)ethylidene]-5,6-dichloro-3-pyridinecarboxamide

Participants

Reaction Conditions

Reaction Steps

A mixture of 5,6-dichloro-3-pyridinecarboxamide (4.0 g, 0.02 mol), dimethylacetamide dimethyl acetal (8 mL) was heated in an oil bath at 120° C. for three hours. The reaction mixture was cooled to room temperature and the solid recrystallised from ethyl acetate:hexane in the presence of activated carbon to give the desired product (2.3 g, 42%) as an orange solid.

Provenance & Evidence