HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5,6-dichloropyridine-3-carbonyl Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5,6-Dichloronicotinic acid | HCID 247987 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 5,6-dichloropyridine-3-carbonyl Chloride | HCID 2782156 | 99% |
Reaction Steps
A mixture of 5,6-dichloronicotinic acid (5.2 g, 27 mmol) in thionyl chloride (50 mL) containing dimethylformamide (2 drops) was heated under reflux conditions for two hours; cooled and concentrated under reduced pressure to afford 5,6-dichloronicotinoyl chloride (5.6 g, 99%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133294 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-3ac7b5632e2f4aee8b3c0e6b1a583c55 |
| Source note | uspto-grants-2000_10 |