Sodium methanethiolate → HCID 23288278, compound

Participants

Reaction Steps

3-(2,3-Dichloro-5-pyridyl)-5-ethylisoxazole (0.71 g, 2.9 mmol) was dissolved in t-butanol (15 mL) and sodium methanethiolate (0.3 g, 4.3 mmol) added. The reaction mixture was heated under reflux with stirring for 3 hours, cooled, and poured onto ice. The resulting cream precipitate was collected by filtration, dissolved in dichloromethane (50 mL) and dried over anhydrous sodium sulphate. Evaporation of the solvent under reduced pressure gave the desired product (0.61 g, 83%) as a cream solid, melting point. 59-62° C.

Provenance & Evidence