4-Nitrobenzaldehyde → 6-(2-Imidazole-1-yl-ethoxy)-2-(4-nitro-benzylidene)-3,4-dihydro-2H-naphthalen-1-one

Participants

Reaction Steps

According to the method of Example 4, 6-(2-imidazole-1-yl-ethoxy)-3,4-dihydro-2H-naphthalen-1-one (0.19 g, 0.74 mmol) was reacted with 4-nitrobenzaldehyde (0.112 g, 0.74 mmol) in 1.5 mL of 4% KOH in ethanol for 3 hours at room temperature to afford 0.195 g (68%) of the title compound as a fine tan powder, mp 184-185° C.: CI-MS m/e 389 (M+), 390 (M+ +1);

Provenance & Evidence