2-Thiophenecarboxaldehyde → HCID 53956948, compound

Participants

Reaction Steps

According to the method of Example 8, 6-(2-imidazole-1-yl-ethoxy)-3,4-dihydro-2H-naphthalen-1-one (0.400 g, 1.56 mmol) was reacted with 2-thiophene carboxaldehyde (0.264 g, 2.35 mmol) in 5.0 mL of 4% KOH in EtOH for 4.5 hours at room temperature to afford 0.369 g (67%) of the title compound as dark yellow crystals, mp 137-138° C.: CI-MS m/e 350 (M+), 351 (M+ +1); 1H-NMR (CDCl3): δ 8.04 (1H, d, J=8.6 Hz), 7.98 (1H, s), 7.59 (1H, s), 7.47 (1H, d, J=4.9 Hz), 7.34 (1H, d, J=3.4 Hz), 7.10 (1H, m), 7.05 (1H, s), 7.01 (1H, s), 6.80 (1H, dd, J=8.6 Hz, J=2.4 Hz), 6.67 (1H, br s), 4.34 (2H, m), 4.25 (2H, m), 3.15 (2H, m), 2.94 (2H, m).

Provenance & Evidence