HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Methylsulfanyl)thiophene-2-carbaldehyde → 6-(2-Imidazole-1-yl-ethoxy)-2-(5-methylsulfanyl-thiophen-2-ylmethylene)-3,4-dihydro-2H-naphthalen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Methylsulfanyl)thiophene-2-carbaldehyde | HCID 2736997 | — |
| Reactant | 6-(2-Imidazole-1-yl-ethoxy)-3,4-dihydro-2H-naphthalen-1-one | HCID 15486912 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Potassium Hydroxide | HCID 14797 | — |
| Product | 6-(2-Imidazole-1-yl-ethoxy)-2-(5-methylsulfanyl-thiophen-2-ylmethylene)-3,4-dihydro-2H-naphthalen-1-one | HCID 54382057 | 75.4% |
Reaction Steps
According to the method of Example 4, 6-(2-imidazole-1-yl-ethoxy)-3,4-dihydro-2H-naphthalen-1-one (0.25 g, 0.98 mmol) was reacted with 5-(methylthio)thiophene-2-carboxaldehyde (0.233 g, 1.47 mmol) in 4 mL of 4% KOH in EtOH for 2 hours at room temperature to afford 0.293 g (36%) of the title compound as a dark yellow powder, mp 102-104° C.: APCI-MS m/e 397.5 (M+ +1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06133303 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-316b9fdc3e77492fa1bf4b790306ac7f |
| Source note | uspto-grants-2000_10 |