4-Formylbenzamide → HCID 178479545, compound

HRID 368325Notes

Reaction equation

HRID 368325 reaction equation
[ClH:1].[NH:2]1[CH:6]=[C:5]([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[C:16](=[O:20])[CH2:15][CH2:14][CH2:13]3)[N:4]=[CH:3]1.[CH:21]1[C:26]([CH:27]=O)=[CH:25][CH:24]=[C:23]([C:29]([NH2:31])=[O:30])[CH:22]=1>[OH-].[K+].CCO>[ClH:1].[NH:2]1[CH:6]=[C:5]([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[C:16](=[O:20])[C:15](=[CH:27][C:26]2[CH:25]=[CH:24][C:23]([C:29]([NH2:31])=[O:30])=[CH:22][CH:21]=2)[CH2:14][CH2:13]3)[N:4]=[CH:3]1

Participants

5

Reactant 2

HCID 117447904-FormylbenzamideHCID 178479625HCID 178479625, compound

Product 1

HCID 178479545HCID 178479545, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14797Potassium HydroxideSolvent

Procedure

According to the method of Example 34, 6-[2-(1H-imidazole-4-yl)-ethoxy]-3,4-dihydro-2H-naphthalen-1-one, monohydrochloride (0.313 g, 1.07 mmol) was reacted with benzamide-4-carboxaldehyde (0.178 g, 1.13 mmol) in 5 mL of 4% KOH in EtOH overnight to afford 0.197 (42%) of the title compound as an off-white powder, mp dec. >230° C.: CI-MS m/e 388 (M+ +1).

Sources & evidence

ORD record
ord-0e9b47634c2342ca80c9bf7ecae79bd1
Source dataset
uspto-grants-2000_10
Patent number
US06133303

Reaction notes

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