3-Methyl-2-thiophenecarboxaldehyde → HCID 178429640, compound

Participants

Reaction Steps

According to the method of Example 4, 6-[2-(1H-imidazole-4-yl)-ethoxy]-3,4-dihydro-2H-naphthalen-1-one, monohydrochloride (0.146 g, 0.50 mmol) was reacted with 3-methyl-thiophene-2-carboxaldehyde (0.095 g, 0.50 mmol) in 5 mL of 4% KOH in EtOH to afford 0.115 g (63%) of the title compound as a coarse cream powder, mp 191-193° C.: CI-MS m/e 365 (M+).

Provenance & Evidence