Potassium Hydroxide → HCID 178515640, compound

HRID 368332Notes

Reaction equation

HRID 368332 reaction equation
C(OC([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][O:15][C:16]2[CH:25]=[CH:24][C:23]3[C:22](=[O:26])[CH2:21][CH2:20][CH2:19][C:18]=3[CH:17]=2)[N:10]=[CH:9]1)=O)(C)(C)C.[OH-:27].[K+]>CCO>[O:27]1[CH:18]=[CH:17][CH:16]=[C:25]1[CH:24]=[C:21]1[CH2:20][CH2:19][C:18]2[C:23](=[CH:24][CH:25]=[C:16]([O:15][CH2:14][CH2:13][C:11]3[N:10]=[CH:9][NH:8][CH:12]=3)[CH:17]=2)[C:22]1=[O:26]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 54451574HCID 54451574, compound

Product 1

HCID 178515640HCID 178515640, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

According to the method of Example 32, 4-[2-(5-oxo-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-ethyl]-imidazole-1-carboxylic acid tert-butyl ester (0.270 g, 0.75 mmol) was reacted with 2-furylaldehyde (0.095 mL, 1.14 mmol) in 5 mL of 4% KOH in EtOH overnight to afford 0.190 g (76%) of the title compound as a foam which solidified on standing to give a dark red powder, mp 57-60° C.: CI-MS m/e 335 (M+ +1).

Sources & evidence

ORD record
ord-c14383f3ccb34167aec4d5f45ae85952
Source dataset
uspto-grants-2000_10
Patent number
US06133303

Reaction notes

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