反应详情

A solution of 17.98 g (0.118 mol) of 3-hydroxy-2-methylbenzoic acid in 200 mL of MeOH was treated with 2.0 mL of conc. H2SO4 and heated at reflux overnight. The solution was concentrated under reduced pressure and diluted with H2O. The product was collected and recrystallized from MeOH/H2O to give 12.85 g (65.6% yield) of a tan solid, mp 74-75° C. The structure was confirmed by NMR and mass spectroscopy. MS m/z 167 (M+H+).

1. temperatureheated
2. temperatureat reflux overnight
3. concentrationThe solution was concentrated under reduced pressure
4. additiondiluted with H2O
5. customThe product was collected
6. customrecrystallized from MeOH/H2O