2-(1H-imidazol-1-yl)-1-phenylethanol → 6-[2-(1H-1-Imidazolyl)-1-phenylethoxy]-1,2,3,4-tetrahydro-1-naphthalenone

Participants

Role	Name	HCID	Charge
Reactant	2-(1H-imidazol-1-yl)-1-phenylethanol	HCID 32239	—
Reactant	6-(2-Imidazole-1-yl-ethoxy)-3,4-dihydro-2H-naphthalen-1-one	HCID 15486912	—
Product	6-[2-(1H-1-Imidazolyl)-1-phenylethoxy]-1,2,3,4-tetrahydro-1-naphthalenone	HCID 10268489	93.7%

Reaction Steps

Following the procedure of Example 78, Step 3, but using 2.63 g (14.0 mmol) of 2-(1H-1-imidazolyl)-1-phenyl-1-ethanol and 2.0 g (12.3 mmol) of 6-[2-(1H-1-imidazolyl)ethoxy]-1,2,3,4-tetrahydro-1-naphthalenone, there was obtained 3.83 g (93.6% yield) of the product as a glass. The structure was confirmed by NMR and mass spectroscopy. MS m/z 333 (M+H+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06133303
Source dataset	uspto-grants-2000_10
ORD ID	ord-76c5db7569924005bd935cbd1915e266
Source note	uspto-grants-2000_10