Pyridine → HCID 18466696, compound

HRID 368362Notes

Reaction equation

HRID 368362 reaction equation
[OH:1][C:2]1[CH:7]=C(C(OC)=O)C=C(OC)N=1.[CH3:14][O:15][C:16]1[CH:21]=[C:20]([C:22](OC)=O)[CH:19]=[C:18]([O:26][CH:27]([CH3:29])[CH3:28])[N:17]=1.N1C=CC=C[CH:31]=1>>[CH3:14][O:15][C:16]1[CH:21]=[C:20](/[C:22](/[CH3:31])=[CH:7]/[CH:2]=[O:1])[CH:19]=[C:18]([O:26][CH:27]([CH3:28])[CH3:29])[N:17]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 18466661HCID 18466661, compoundHCID 178498597HCID 178498597, compound

Product 1

HCID 18466696HCID 18466696, compound

Procedure

2-Hydroxy-6-methoxy-4-carbomethoxy-pyridine was isopropylated into 2-methoxy-6-isopropoxy-4-carbomethoxy-pyridine in a similar manner to that described in Step 1 of Example 1. The pyridine derivative thus obtained was converted into an aldehyde in a similar manner to that described in Step 2 of Example 1. This aldehyde was treated in a similar manner to that described in Steps 3 to 5 of Example 1 and Steps 1 and 2 of Example 2 to give the title compound.

Sources & evidence

ORD record
ord-e4b5b68673de463bbc3d4db53999f9f8
Source dataset
uspto-grants-2000_10
Patent number
US06133283

Reaction notes

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