2-Aminothiophenol → Benzo(d)thiazol-2-amine

Participants

Reaction Steps

If the desired 2-amino benzenethiol 14-scheme 12 is not commercially available it can be synthesized by reaction of the phenyl aniline with the thiocyanate anion in the presence of an oxidant (like bromine) to produce the 2-amino benzthiazole. This thiazole can then be hydrolyzed to the desired 2-amino benzenethiol 12-scheme 10 with a strong base like NaOH in a protic solvent (i.e., EtOH).

Provenance & Evidence