Triethylamine hydrofluoride → trans-N-(2-benzyloxycyclohexyl)-N'-(2-hydroxy-4-nitrophenyl)urea

Participants

Reaction Steps

To a solution of trans-N-(2-Benzyloxycyclohexyl)-N'-(2-tert-butyldimethylsilyloxy-4-nitrophenyl) urea (100 mg, 0.2 mmol) in acetonitrile (2 mL), triethylamine hydrofluoride (0.1 mL, 0.6 mmol) was added. The reaction mixture was stirred at room temperature for 30 minutes. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was dried over MgSO4, filtered and concentrated under reduced pressure to give product (73 mg, 95%). EI-MS m/z 386 (M+H)+.

Provenance & Evidence