反应详情

温度

80 °C

To a solution of t-butyl isocyanate (400 mg, 4.04 mmol) in toluene, the 2-amino-5-nitrophenol (622 mg, 4.04 mmol) was added. The reaction mixture was stirred at 80° C. for 24 hours, then cooled to room temperature. The product was purified by precipitation from toluene and filtering (864 mg, 85%). m.p: 99.0-101.1° C.; EI-MS m/z 254 (M+H)+.

1. temperaturecooled to room temperature
2. customThe product was purified by precipitation from toluene
3. filtrationfiltering (864 mg, 85%)