Methanol → 3,5,6-Trifluoro-4-methylpyridin-2-amine

HRID 368414Notes

Reaction equation

HRID 368414 reaction equation
CO.C([NH:10][C:11]1[C:16]([F:17])=[C:15]([CH3:18])[C:14]([F:19])=[C:13]([F:20])[N:12]=1)C1C=CC=CC=1>[Pd].C(O)(=O)C>[NH2:10][C:11]1[C:16]([F:17])=[C:15]([CH3:18])[C:14]([F:19])=[C:13]([F:20])[N:12]=1

Participants

5

Reactant 2

HCID 887MethanolHCID 221212552-Benzylamino-3,5,6-trifluoro-4-methylpyridine

Product 1

HCID 125080923,5,6-Trifluoro-4-methylpyridin-2-amine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

To 4 ml of methanol were added all amount of the crude 2-benzylamino-3,5,6-trifluoro-4-methylpyridine as described above together with 0.18 g of 10% palladium on carbon and 2 ml of acetic acid, and the mixture was hydrogenated at 50° C. for one day. The catalyst was separated by filtration, and the solvent and the like were distilled off under reduced pressure to obtain 1.35 g of the title compound as a colorless solid.

Workup

  1. customThe catalyst was separated by filtration
  2. distillationthe solvent and the like were distilled off under reduced pressure

Sources & evidence

ORD record
ord-60f3d879aac04f81ace487ab4f996456
Source dataset
uspto-grants-2000_10
Patent number
US06133284

Reaction notes

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